Ashesh Chattopadhyay, Pedram Hassanzadeh, Devika Subramanian
Nonlinear processes in geophysics·
2020·
cited by 168
Climate & Environment
Neural Networks and Reservoir Computing
partially solved
importance 4/10
scale stated
Predicting the short-term evolution and long-term statistics of a multiscale chaotic Lorenz 96 system when only the large-scale variables are observable and the smaller-scale processes are never known.
Miquel Llorens-Monteagudo, Alejandro Torres-Forné, José A. Font, Antonio Marquina
Classical and Quantum Gravity·
2019·
cited by 24
Physics & Astronomy
Pulsars and Gravitational Waves Research
partially solved
importance 4/10
scale stated
Gravitational-wave interferometers like advanced LIGO produce transient noise signals (glitches) that must be classified and separated from real astrophysical signals.
Dong Wook Kim, Sanghoon Lee, Sunmo Kwon, Woong Nam, In–Ho Cha, Hyung Jun Kim
Scientific Reports·
2019·
cited by 320
Medicine & Health
Machine Learning in Healthcare
ai assisted
importance 4/10
scale stated
Traditional Cox proportional hazards models may be too simplistic to accurately predict survival outcomes for oral squamous cell carcinoma patients.
Zhongqi Miao, Kaitlyn M. Gaynor, Jiayun Wang, Ziwei Liu, Oliver Muellerklein, Mohammad Sadegh Norouzzadeh, Alex McInturff, Rauri C. K. Bowie et al.
Scientific Reports·
2019·
cited by 136
Conservationists need to automatically identify and classify wildlife species in large camera-trap image datasets, which is slow and error-prone manually.
Ameni Trabelsi, Mohamed Amine Chaâbane, Asa Ben‐Hur
Bioinformatics·
2019·
cited by 153
The relative merit of CNN, RNN, and hybrid deep learning architectures for predicting DNA- and RNA-binding specificity was unclear from existing studies.
Zhenpeng Zhou, Steven Kearnes, Li Li, Richard N. Zare, Patrick F. Riley
Scientific Reports·
2019·
cited by 401
Optimizing molecules for drug discovery, including maximizing drug-likeness while maintaining similarity to an original molecule during medicinal chemistry lead optimization.
Ingoo Lee, Jongsoo Keum, Hojung Nam
PLoS Computational Biology·
2019·
cited by 674
Identifying drug-target interactions experimentally is costly and labor-intensive, and conventional protein descriptors were insufficiently informative for accurate in silico prediction.
Buzhong Zhang, Jinyan Li, Qiang Lü
BMC Bioinformatics·
2018·
cited by 140
Accurately predicting 8-state protein secondary structure, which serves as an information bridge between primary sequence and tertiary structure for structure-based analysis.
Sebastian Scher
Geophysical Research Letters·
2018·
cited by 303
Climate & Environment
Meteorological Phenomena and Simulations
partially solved
importance 4/10
scale stated
Whether deep learning can emulate the dynamics of weather and climate general circulation models to enable data-driven forecasting.
Enrico Mossotto, James John Ashton, Tracy A F Coelho, R Mark Beattie, Ben D. MacArthur, Sarah A. Ennis
Scientific Reports·
2017·
cited by 157
Medicine & Health
Inflammatory Bowel Disease
partially solved
importance 4/10
scale stated
Accurate diagnosis of paediatric inflammatory bowel disease subtypes (Crohn's, ulcerative colitis, IBDU) is needed for prompt, effective treatment.
Peter Ukkonen, Agostino Manzato, Antti Mäkelä
Journal of Applied Meteorology and Climatology·
2017·
cited by 31
Climate & Environment
Meteorological Phenomena and Simulations
partially solved
importance 4/10
scale stated
Identifying thunderstorm occurrences over Finland from reanalysis data using multiple environmental predictors.
Adam Rubin, Avishay Gal‐Yam
The Astrophysical Journal·
2016·
cited by 42
Astronomers needed a systematic, unbiased way to classify Type II supernova light curves ahead of upcoming large transient surveys.
Kanichiro Matsumura, Carlos F. Gaitán, K. SUGIMOTO, Alex J. Cannon, William W. Hsieh
The Journal of Agricultural Science·
2014·
cited by 100
Forecasting maize yields in Jilin, China from 1962-2004 using climate conditions and fertilizer data, which is hard to obtain.
Zheng Wang, Michael O’Boyle
ACM Transactions on Architecture and Code Optimization·
2013·
cited by 46
Software & Coding
Parallel Computing and Optimization Techniques
ai assisted
importance 4/10
scale stated
Automatically partitioning streaming parallel programs for multicore systems is difficult because the ideal mapping depends on both the program and the underlying architecture.
Uvarani Vignesh, R. Parvathi, K. Gokul Ram
Results in Engineering·
2024·
cited by 24
Predicting protein secondary structure accurately is difficult, and better predictions are needed to understand protein function.
Takeshi Yamaguchi, Yuya Takahashi, Yoshihiro Sasaki
Sensors·
2023·
cited by 20
Medicine & Health
Lower Extremity Biomechanics and Pathologies
partially solved
importance 4/10
scale stated
Measuring three-directional ground reaction forces during walking normally requires lab force plates; a wearable shoe sole sensor system was developed to predict them.
Shih-Lin Lin
Scientific Reports·
2023·
cited by 35
Tire defects such as cracks and debris are hard to detect manually, creating safety risks and labor costs for drivers and manufacturers.
Jongbeom Kim, Gyuwon Kim, Lei S. Li, Pengfei Zhang, Jin Young Kim, Yeonggeun Kim, Hyung Ham Kim, Lihong V. Wang et al.
Light Science & Applications·
2022·
cited by 126
Medicine & Health
Photoacoustic and Ultrasonic Imaging
solved
importance 4/10
scale stated
Superresolution photoacoustic imaging achieves very high spatial resolution but requires superimposing many raw image frames, sacrificing temporal resolution and making imaging slow.
Hongwei Li, Aurore Menegaux, Benita Schmitz‐Koep, Antonia Neubauer, Felix J.B. Bäuerlein, Suprosanna Shit, Christian Sorg, Bjoern H. Menze et al.
Human Brain Mapping·
2021·
cited by 28
Medicine & Health
Medical Image Segmentation Techniques
partially solved
importance 4/10
scale stated
The claustrum's delicate, sheet-like structure made it infeasible to segment with conventional methods in human brain MRI, limiting in vivo research.
Mahtab Jahanbani Fard, Sattar Ameri, R. Darin Ellis, Ratna Babu Chinnam, Abhilash K. Pandya, Michael D. Klein
International Journal of Medical Robotics and Computer Assisted Surgery·
2017·
cited by 188
Robotics & Autonomy
Surgical Simulation and Training
partially solved
importance 4/10
scale stated
Surgical skill assessment has predominantly been subjective, lacking objective automated evaluation of surgeon performance.
Kehinde O. Aina, Sehoon Ha
Artificial Life and Robotics·
2025·
cited by 8
Robotics & Autonomy
Reinforcement Learning in Robotics
partially solved
importance 4/10
scale stated
Multiple robots working in narrow, confined environments suffer congestion and interference that hinder collective task performance, and coordinating them without explicit communication is hard.
Gunjargal Lkhagvadorj, Tsolmon Sodnomdavaa
Journal of risk and financial management·
2025·
cited by 10
Business & Industry
Financial Distress and Bankruptcy Prediction
partially solved
importance 4/10
scale stated
Detecting financial statement fraud is hard under weak regulatory oversight, information asymmetry and severe class imbalance.
Wendkûuni C. Ouédraogo, Laura Plein, Kader Kaboré, Andrew Habib, Jacques Klein, David Lo, Tegawendé François Bissyandé
Empirical Software Engineering·
2025·
cited by 16
Software & Coding
Software Testing and Debugging Techniques
partially solved
importance 4/10
scale stated
Automated test generation tools struggle to produce relevant test inputs, limiting the bug-detection effectiveness of generated tests.
Qianheng Zhang, Song Gao, Wei Chen, Yibo Zhao, Ying Nie, Ziru Chen, Shijie Chen, Yu Su et al.
Transactions in GIS·
2025·
cited by 16
Software & Coding
Geographic Information Systems Studies
partially solved
importance 4/10
scale stated
It was unclear whether large language models can actually automate real-world geospatial analysis and GIS workflows, and rigorous evaluation of this capability was lacking.