Machine Learning to Predict Enzyme–Substrate Interactions in Elucidation of Synthesis Pathways: A Review
Experimentally determining enzyme-substrate interactions is slow and costly, and physics-based simulations are too slow for large search spaces.
1,138 of 1,138 verified cases.
Experimentally determining enzyme-substrate interactions is slow and costly, and physics-based simulations are too slow for large search spaces.
Detecting railway wheel defects early despite interfering vibrations that cause false alarms during operation.
Predicting ore deposit locations is hindered by scarce labeled geological images, small irregular features with high image similarity, and hard-to-quantify prospecting factors.
Laser-based metal additive manufacturing (PBF-LB/M, DED-LB/M) frequently forms defects and existing machines lack closed-loop control, making processes hard to control.
GAN-based MRI reconstruction from under-sampled data normally requires large training sets of raw k-space patient data, which is difficult to gather in clinical practice.
Traditional short-term wind power forecasting struggles with large, highly volatile time-series data and limited processing capacity.
Assessing surgeons' technical skill from video is time-consuming and subjective, and labeling raw surgical video datasets for skill analysis is hard.
Long MRI pulse sequence acquisition times restrict patient tolerability and access in musculoskeletal imaging.
Ecologists must review enormous volumes of camera trap images to identify wildlife, which delays research and actionable insights.
Short-term forecasting of clustered hybrid renewable energy systems (wind, photovoltaic, concentrating solar power) is difficult due to spatial and temporal uncertainties.
Family violence in Bangladesh during the COVID-19 lockdown needed to be forecast to anticipate social harm.
Predicting the lattice thermal conductivity of crystal materials is hard because usable datasets are scarce, limiting data-driven materials science.
Predicting the quaternary structure of dimeric protein complexes, which is useful for function analysis, protein engineering and drug design.
Reconstructing neurons, synapses, and organelles from nanometer-resolution volumetric microscopy requires scalable segmentation tools that can exploit scarce expert annotations and abundant unlabeled data.
Machine-learning models built on human microbiome data suffered from scarce metagenomics-specific software, overoptimistic evaluation, and poor generalization across studies.
Detecting and diagnosing glaucoma from retinal images using machine learning classification algorithms.
Predicting human diseases from microbiome (metagenomic) data suffers information loss and severe overfitting because datasets are high-dimensional with few samples.
Most structural damage detection techniques fail to automatically identify novelties such as damage or abnormal behavior from dynamic measurements, making human decisions necessary.
The rapid flood of clinical LLM studies (roughly 3.2 papers per day) makes manual curation and review of the evidence base infeasible.
Building energy consumption is hard to forecast accurately due to uncertainty and noise, hindering energy-saving measures.
Characterising the gut microbiome for precision medicine requires extracting insight from complex multi-omics datasets (metagenomics, metatranscriptomics, glycomics, metabolomics).
People with dysarthric speech (discontinuous, uncontrolled volume, slow or explosive pronunciation) are poorly served by standard automatic speech recognition.
Accurate segmentation of medical images is needed for clinical analysis, and the deep learning literature on it is large and disorganized.
Predicting human diseases from gut microbiome data is difficult, with ML showing promise for some conditions but lacking efficacy for others.