Carlos Torroja, Fátima Sánchez‐Cabo
Frontiers in Genetics·
2019·
cited by 51
Bulk RNA-Seq cannot distinguish whether observed expression changes come from shifting cell-type proportions or aberrant behavior of a specific cell type, while single-cell experiments remain complex and expensive.
Jian Mao, Hua He
Journal of intelligent medicine·
2024·
cited by 24
Fluorescence imaging faces challenges in efficiently acquiring high signal-to-noise ratio images, improving spatiotemporal resolution, and conducting precise quantitative analysis.
Yuequan Bao, Hui Li
Structural Health Monitoring·
2020·
cited by 372
Conventional vibration-based methods struggle to detect damage in actual structures due to incomplete monitoring data, intense uncertainties, and coupled environmental effects.
Mohamed Abdellatif Hussein, Hesham Hassan, Mohammad Nassef
PeerJ Computer Science·
2019·
cited by 179
Education & Everyday
Natural Language Processing Techniques
ai assisted
importance 5/10
scale stated
Manually scoring exam essays is slow and unreliable, creating a need for objective automated grading.
Masato Sakai, Akihisa Sakurai, Siyuan Lu, J. Francisco Sibón Olano, Conrad M Albrecht, Hendrik F. Hamann, Marcus Freitag
Proceedings of the National Academy of Sciences·
2024·
cited by 18
Finding figurative Nazca geoglyphs was extremely slow: only 430 were discovered over nearly a century, and small relief-type ones are hard to see.
Changjian Xie, Xiaolei Zhu, David R. Yarkony, Hua Guo
The Journal of Chemical Physics·
2018·
cited by 90
Accurately representing coupled diabatic potential energy matrices of molecules, needed to model non-adiabatic photodissociation dynamics.
Adrian J. Jervis, Pablo Carbonell, María Vinaixa, Mark S. Dunstan, Katherine A. Hollywood, Christopher Robinson, Nicholas J. W. Rattray, Cunyu Yan et al.
ACS Synthetic Biology·
2018·
cited by 118
Optimizing multigene production pathways in microbes requires screening huge combinatorial ribosome binding site (RBS) libraries, and methods to predict optimal RBS combinations were lacking.
Christopher J. Shallue, Andrew M. Vanderburg
The Astronomical Journal·
2018·
cited by 368
Physics & Astronomy
Stellar, planetary, and galactic studies
solved
importance 4/10
scale stated
Weak Kepler signals at low signal-to-noise are hard to distinguish from false positives, blocking accurate occurrence rates of Earth-sized planets.
Kapil Vaidya, Anshuman Dutt, Vivek R. Narasayya, Surajit Chaudhuri
Proceedings of the VLDB Endowment·
2021·
cited by 20
Software & Coding
Advanced Database Systems and Queries
solved
importance 4/10
scale stated
Parametric query optimization must cache a small set of plans for parameterized queries and then quickly pick the best cached plan per query instance.
Eun‐Young Ji, Yong‐Jae Moon, Jongyeob Park, Jin‐Yi Lee, Dong‐Hun Lee
Journal of Geophysical Research Space Physics·
2013·
cited by 45
Physics & Astronomy
Ionosphere and magnetosphere dynamics
partially solved
importance 4/10
scale stated
Near-real-time forecasting of the Kp geomagnetic activity index was addressed by comparing four forecast models based on neural networks and support vector machines using solar wind data and preliminary Kp values.
Isam Qasem, Amjad Alsakarneh
Journal of Manufacturing and Materials Processing·
2025·
cited by 11
Predicting material removal rate and surface roughness in electrical discharge machining (EDM) is difficult because of complex physical events in the electrode gaps.
Y. Sultan Abylkairov, Matthew C Edwards, Daniil Orel, Ayan Mitra, Bekdaulet Shukirgaliyev, Ernazar B. Abdikamalov
Machine Learning Science and Technology·
2024·
cited by 7
Physics & Astronomy
Pulsars and Gravitational Waves Research
ai assisted
importance 4/10
scale stated
Determining the equation of state of nuclear matter from gravitational waves of rotating core-collapse supernovae requires classifying signals generated by different equations of state.
Muhammad Faseeh, Abdul Jaleel, Naeem Iqbal, Anwar Ghani, Akmalbek Bobomirzaevich Abdusalomov, Asif Mehmood, Young Im Cho
Mathematics·
2024·
cited by 39
Automated essay scoring systems face persistent challenges in delivering accurate and efficient evaluations.
Yagyank Srivastava, Ankit Jain
Journal of Applied Physics·
2023·
cited by 21
Predicting the thermal conductivity of materials is slow and limited by scarce high-quality data.
Vahid Ebrahimi, Till Stephan, Jiah Kim, Pablo Carravilla, Christian Eggeling, Stefan Jakobs, Kyu Young Han
Communications Biology·
2023·
cited by 44
STED super-resolution microscopy damages and bleaches samples because of long pixel dwell times, limiting live-cell imaging.
Caleb Ziems, William Held, Omar Shaikh, Jiaao Chen, Zhehao Zhang, Diyi Yang
Computational Linguistics·
2023·
cited by 559
Whether large language models can reliably classify and explain social phenomena (e.g., persuasiveness, ideology) for computational social science.
Keren Li, Matthew S. Carroll, Reza Vafabakhsh, Xiaozhong A. Wang, Ji-Ping Wang
Nucleic Acids Research·
2022·
cited by 40
Measuring intrinsic DNA cyclizability/bendability experimentally (via loop-seq) is laborious; a fast computational predictor was needed.
Xin Liu, Tao Sun, Anna Shcherbina, Qin Li, Inga Jarmoskaite, Kalli Kappel, Gokul Ramaswami, Rhiju Das et al.
Nature Communications·
2021·
cited by 25
It was poorly understood how RNA sequence and structure determine the efficiency and specificity of A-to-I RNA editing, hindering interpretation of known editing events and engineering of desired edits.
Kazunori Yoshida, Shun Kawai, Masaya Fujitani, Satoshi Koikeda, Ryuji Kato, Tadashi Ema
Scientific Reports·
2021·
cited by 26
Improving the heat stability of Burkholderia cepacia lipase without assaying all 8,000 possible triple mutants.
Mateusz Choiński, Mateusz Rogowski, Piotr Tynecki, Dries P. J. Kuijper, Marcin Churski, Jakub W. Bubnicki
Lecture notes in computer science·
2021·
cited by 33
Manually labeling camera trap images of mammals for wildlife monitoring is slow and hard to scale; the paper automates species identification in Białowieża Forest, Poland.
Joël Lukas Lavanchy, Joël Zindel, Kadir Kirtac, Isabell Twick, Enes Hosgor, Daniel Candinas, Guido Beldi
Scientific Reports·
2021·
cited by 148
Medicine & Health
Surgical Simulation and Training
partially solved
importance 4/10
scale stated
Manual assessment of surgeons' skills is time-consuming, subjective and prone to inconsistent interpretation.
Yutaka Saitō, Misaki Oikawa, Takumi Sato, Hikaru Nakazawa, Tomoyuki Ito, Tomoshi Kameda, Koji Tsuda, Mitsuo Umetsu
ACS Catalysis·
2021·
cited by 70
Directed evolution of enzymes is slow, and it was unclear how machine-learning training data composition affects guidance of sequence-space exploration.
Mohammed Sidi Yakoub, Sid‐Ahmed Selouani, Brahim-Fares Zaidi, Asma Bouchair
EURASIP Journal on Audio Speech and Music Processing·
2020·
cited by 65
Medicine & Health
Speech Recognition and Synthesis
partially solved
importance 4/10
scale stated
Automatic speech recognizers perform poorly on dysarthric speech, making voice technology unreliable for affected speakers.
Christin Carl, Fiona Schönfeld, Ingolf Profft, Alisa Klamm, Dirk Landgraf
European Journal of Wildlife Research·
2020·
cited by 55
Camera trap studies generate thousands of images that are expensive and time-consuming to analyze manually.