Colleen O’Sullivan, Daniel Hsiang‐Te Tsai, Ian Chang-Yen Wu, Emanuela Boselli, Carmel M Hughes, Deepak Padmanabhan, Yingfen Hsia
BMC Infectious Diseases·
2023·
cited by 29
Medicine & Health
Neonatal and Maternal Infections
ai assisted
importance 7/10
scale stated
Neonatal sepsis has non-specific signs, treatment is labour-intensive, and antimicrobial resistance complicates empiric antibiotic choice.
David F. Locher, Lorenzo Cardarelli, Markus Michael Müller
Quantum·
2023·
cited by 36
Physics & Astronomy
Quantum Computing Algorithms and Architecture
ai assisted
importance 7/10
scale stated
Quantum processors require active error correction, and designing effective strategies for detecting and correcting varied errors (including correlated errors and qubit loss) is difficult.
Walid Ben Elmir, Hemmak Allaoua, Benaoumeur Senouci
Information·
2023·
cited by 65
Medicine & Health
Blood donation and transfusion practices
ai assisted
importance 7/10
scale stated
Blood supply chains suffer from uncertain demand, causing wastage and shortages when inventory is insufficient.
Guannan Huang, Yani Guo, Ye Chen, Zhengwei Nie
Materials·
2023·
cited by 165
Traditional experimental and simulation-based discovery of new materials is slow and resource-intensive, motivating faster computational approaches.
Yue Zhao, Jie Zhang, Dayu Hu, Hui Yan Qu, Ye Tian, Xiaoyu Cui
Micromachines·
2022·
cited by 42
Detection, segmentation and classification of breast cancer in histopathology images is difficult; the study reviews deep learning approaches to it.
Yan Chen, Zepang Sun, Wanlan Chen, Changyan Liu, Ruoyang Chai, Jingjing Ding, Wen Liu, Xianzhen Feng et al.
Frontiers in Immunology·
2021·
cited by 71
Medicine & Health
Cancer Immunotherapy and Biomarkers
ai assisted
importance 7/10
scale stated
Gastric cancer responds heterogeneously to immunotherapy, and identifying immune subtypes could improve therapeutic strategies.
Fetulhak Abdurahman, Kinde Anlay Fante, Mohammed Aliy Mohammed
BMC Bioinformatics·
2021·
cited by 139
Medicine & Health
Digital Imaging for Blood Diseases
ai assisted
importance 7/10
scale stated
Manual microscopic examination of blood smears, the gold standard for malaria diagnosis, depends on skilled microscopists who are scarce in remote developing regions.
Brijesh D. Patel, Partho P. Sengupta
Expert Review of Cardiovascular Therapy·
2020·
cited by 46
Medicine & Health
Artificial Intelligence in Healthcare
partially solved
importance 7/10
scale stated
Traditional statistical models cannot predict individual-level risk of cardiovascular events such as heart failure and arrhythmias.
Jun Wang, Xiuqing Zhang, Lixin Cheng, Yonglun Luo
RNA Biology·
2019·
cited by 102
Predicting the on-target activity and off-target specificity of CRISPR-Cas9 guide RNAs is difficult, yet decisive for safe and effective gene editing.
Tshepang Duncan Morapedi, Ibidun Christiana Obagbuwa
Frontiers in Artificial Intelligence·
2023·
cited by 29
Predicting PM2.5 particulate pollution in South African cities, where reliable air quality sensors are scarce.
Jiayao Zheng, Yu Wang, Qianying Liang, Lun Cui, Liqun Wang
Molecules·
2024·
cited by 32
Traditional antibody discovery and optimization is time-consuming and resource-intensive, slowing development of antibody diagnostics and therapeutics.
Anila Sebastian, Omar Elharrouss, Somaya Ali Al-Maadeed, Noor Almaadeed
Diagnostics·
2023·
cited by 110
Medicine & Health
Retinal Imaging and Analysis
ai assisted
importance 7/10
scale stated
Diabetic retinopathy damages the eyes of long-term diabetes patients, and early automatic detection is needed to avoid vision loss.
Stewart Muchuchuti, Serestina Viriri
Journal of Imaging·
2023·
cited by 136
Medicine & Health
Retinal Imaging and Analysis
partially solved
importance 7/10
scale stated
Manual detection of retinal diseases such as glaucoma, diabetic retinopathy and AMD is time-consuming, tedious and lacks repeatability.
Varnavas D. Mouchlis, Antreas Afantitis, Angela Serra, Michele Fratello, Anastasios G. Papadiamantis, Vassilis Aidinis, Iseult Lynch, Dario Greco et al.
International Journal of Molecular Sciences·
2021·
cited by 352
Medicine & Health
Computational Drug Discovery Methods
ai assisted
importance 7/10
scale stated
De novo drug design, generating novel molecular structures from atomic building blocks, is difficult and costly with conventional structure- or ligand-based methods.
Swaroop Aradhya, Flavia M. Facio, Hillery C. Metz, Toby R. Manders, Alexandre Colavin, Yuya Kobayashi, Keith Nykamp, Britt A. Johnson et al.
American Journal of Medical Genetics Part C Seminars in Medical Genetics·
2023·
cited by 56
Medicine & Health
Artificial Intelligence in Healthcare and Education
ai assisted
importance 7/10
scale stated
Genomic data volumes are exceeding human capacity to rapidly and reproducibly analyze complex molecular data for timely diagnosis and management of genomic disorders.
Noam Brown, Tüomas Sandholm
Science·
2019·
cited by 583
Mathematics
Artificial Intelligence in Games
solved
importance 6/10
scale stated
AI had surpassed humans in two-player games, but six-player no-limit Texas hold'em poker remained a much harder, unsolved challenge.
Nathan J. Szymanski, Bernardus Rendy, Yuxing Fei, Rishi E. Kumar, Tanjin He, David Milsted, Matthew J. McDermott, Max C. Gallant et al.
Nature·
2023·
cited by 999
Synthesizing novel inorganic materials is slow and labor-intensive; the work aimed to autonomously accelerate solid-state synthesis of targeted compounds.
Morgan C. Thomas, Pierre G. Matricon, Robert F. Gillespie, Maja Napiórkowska, Hannah Neale, Jonathan S. Mason, Jason Brown, Kaan Harwood et al.
Nature Communications·
2025·
cited by 24
Finding novel small-molecule ligands for the adenosine A2A receptor from protein structure alone, without prior knowledge of ligand chemistry.
Léo Baty, Kai Jungel, Patrick S. Klein, Axel Parmentier, Maximilian Schiffer
Transportation Science·
2024·
cited by 69
Logistics providers struggle to plan same-day deliveries: stochastic optimization is too slow online and reinforcement learning struggles with high-dimensional combinatorial problems.
Kolja Stahl, Andrea Graziadei, Therese Dau, Oliver Brock, Juri Rappsilber
Nature Biotechnology·
2023·
cited by 161
Predicting accurate structures for challenging proteins, such as those undergoing conformational changes or with few homologous sequences, where AlphaFold2 underperforms.
Yue Li, Yijun P. Su, Min Yi Guo, Xiaofei Han, Jiamin Liu, Harshad D. Vishwasrao, Xuesong Li, Ryan Patrick Christensen et al.
Nature Methods·
2022·
cited by 123
Science & Research
Advanced Image Processing Techniques
solved
importance 6/10
scale stated
Deconvolution of 3D fluorescence microscopy images is slow and artifact-prone with existing methods.
Avantika Lal, Zachary Chiang, Nikolai Yakovenko, Fabiana M. Duarte, Johnny Israeli, Jason Daniel Buenrostro
Nature Communications·
2021·
cited by 66
Low cell count, low-coverage or noisy ATAC-seq data limits detection of active regulatory regions in the genome.
Jun Cheng, Thi Yen Duong Nguyen, Kamil J. Cygan, Muhammed Hasan Çelik, William Guy Fairbrother, Žiga Avsec, Julien Gagneur
Genome biology·
2019·
cited by 234
Predicting how genetic variants affect splicing (exon skipping, splice site choice, pathogenicity) is difficult but highly relevant to human genetics.
Hui Kwon Kim, Younggwang Kim, Sungtae Lee, Seonwoo Min, Jung Yoon Bae, Jae Woo Choi, Jinman Park, Dongmin Jung et al.
Science Advances·
2019·
cited by 237
Predicting SpCas9 gene-editing activity at arbitrary target sequences was unreliable, limiting CRISPR-based editing.