Revolutionizing sepsis diagnosis using machine learning and deep learning models: a systematic literature review

Muhammad Zubair, Irfanud Din, Nadeem Sarwar, Elov Botir Boltayevich, Sаmаriddin Mаkhmudov, Zouheir Trabelsi

BMC Infectious Diseases 2025 review cited by 29

importance 7/10 ai assisted Sepsis Diagnosis and Treatment critical care stage: research mixed

Sepsis is life-threatening and early detection is difficult; delays significantly worsen patient outcomes.

Sepsis can lead to organ failure and death, making earlier detection clinically critical.

This is a systematic review synthesizing 80 studies of ML/DL approaches (e.g., LSTM, transformers, ensembles) for early sepsis prediction, mainly in ICU settings.

80 studies included; no model performance metrics stated in abstract

Synthesizes existing ML/DL sepsis-prediction research to inform future work.

Venue BMC Infectious Diseases
Published 2025
Work type review
Authors Muhammad Zubair, Irfanud Din, Nadeem Sarwar, Elov Botir Boltayevich, Sаmаriddin Mаkhmudov, Zouheir Trabelsi
Citations 29 (OpenAlex, at import time)
References 98
Model or method Reviewed models include LSTM, transformers, ensemble methods
Organization not stated in source
Primary source https://doi.org/10.1186/s12879-025-11423-2
Open access gold
Keywords sepsis, machine learning, deep learning, systematic review, ICU, early detection
7 / 10

significant — thousands to millions affected

Abstract states sepsis is life-threatening, causes organ failure and death, and early detection is vital; review covers 80 studies, indicating major clinical impact.

Basis: stated. The source itself states the scale. Stated scale: not stated in source. Method and limits.

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