Unlocking HDR-mediated nucleotide editing by identifying high-efficiency target sites using machine learning

Aidan R. O’Brien, Laurence O. W. Wilson, Gaétan Burgio, Denis C. Bauer

Scientific Reports 2019 article cited by 48

importance 6/10 partially solved CRISPR and Genetic Engineering gene editing stage: research

Precise single-nucleotide editing via HDR is inefficient, hampering validation of genomic disease associations.

Efficient nucleotide editing is needed to confirm which genetic variants cause disease.

A machine learning model analyzed a novel mouse dataset to identify efficiency-governing factors, finding ssODN sequence composition is key, and predicted high-efficiency target sites; findings were built into the CUNE tool.

Model improves HDR efficiency by 83% compared to traditionally chosen targets

The CUNE tool enables selection of higher-efficiency target sites for nucleotide editing experiments.

Venue Scientific Reports
Published 2019
Work type article
Authors Aidan R. O’Brien, Laurence O. W. Wilson, Gaétan Burgio, Denis C. Bauer
Citations 48 (OpenAlex, at import time)
References 53
Model or method not stated in source
Organization not stated in source
Primary source https://doi.org/10.1038/s41598-019-39142-0
Open access gold
Keywords CRISPR, HDR, machine learning, nucleotide editing, ssODN, CUNE
6 / 10

significant — thousands to millions affected

Validating genomic disease associations via nucleotide editing is broadly important to genetic disease research; 83% HDR efficiency gain is a real but methodological advance with no stated beneficiary scale.

Basis: inferred. Judged from the source text, which gives no explicit scale. Stated scale: not stated in source. Method and limits.

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