Tailoring industrial enzymes for thermostability and activity evolution by the machine learning-based iCASE strategy

Nan Zheng, Yongchao Cai, Zehua Zhang, Huimin Zhou, Yu Deng, Shuang Du, Mengting Tu, Wei Fang et al.

Nature Communications 2025 article cited by 75

importance 5/10 ai assisted Enzyme Catalysis and Immobilization industrial biotech stage: research

Engineering industrial enzymes that combine high activity with thermostability is difficult due to the stability-activity trade-off.

Better enzymes reduce costs and enable new industrial bioprocesses.

The iCASE strategy uses structure-based supervised machine learning to predict enzyme function and fitness, guiding variant engineering.

Robust prediction across datasets; validated on four enzyme types; no numeric metrics stated

Provides a validated ML strategy to guide future enzyme fitness evolution research.

Venue Nature Communications
Published 2025
Work type article
Authors Nan Zheng, Yongchao Cai, Zehua Zhang, Huimin Zhou, Yu Deng, Shuang Du, Mengting Tu, Wei Fang et al.
Citations 75 (OpenAlex, at import time)
References 68
Model or method structure-based supervised machine learning (iCASE strategy)
Organization not stated in source
Primary source https://doi.org/10.1038/s41467-025-55944-5
Open access gold
Keywords machine learning, enzyme engineering, thermostability, fitness prediction, epistasis
5 / 10

real but narrower advance

Abstract calls high-activity stable enzymes a grail of enzyme evolution; validated ML strategy across four enzyme types is a real but pre-application industrial biotech advance.

Basis: inferred. Judged from the source text, which gives no explicit scale. Stated scale: not stated in source. Method and limits.

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