Sequential regulatory activity prediction across chromosomes with convolutional neural networks

David R. Kelley, Yakir Reshef, Maxwell L. Bileschi, David Belanger, Cory Y. McLean, Jasper Snoek

Genome Research 2018 preprint cited by 534

importance 7/10 solved Genomics and Chromatin Dynamics genomics stage: research

Predicting which DNA sequences act as regulatory elements and how genetic variants influence gene expression in specific cell types, from sequence alone.

Such predictions help explain genomic function and support fine-mapping of disease loci.

A convolutional neural network system predicts cell-type-specific epigenetic and transcriptional profiles from DNA sequence, identifying promoters and distal regulatory elements to make gene expression predictions.

Predictions of variant influence on expression align well with causal eQTL variants in human populations; quantitative metrics not stated in source.

The model's predictions support mechanistic hypotheses and fine-mapping of disease loci, per the authors.

Venue Genome Research
Published 2018
Work type preprint
Authors David R. Kelley, Yakir Reshef, Maxwell L. Bileschi, David Belanger, Cory Y. McLean, Jasper Snoek
Citations 534 (OpenAlex, at import time)
References 71
Model or method convolutional neural networks
Organization not stated in source
Primary source https://doi.org/10.1101/gr.227819.117
Open access green
Keywords CNN, gene regulation, epigenetics, eQTL, disease loci
7 / 10

significant — thousands to millions affected

Predicting cell-type-specific regulatory activity and variant effects from sequence aids understanding genomic function and fine-mapping disease loci; foundational capability; no scale stated.

Basis: inferred. Judged from the source text, which gives no explicit scale. Stated scale: not stated in source. Method and limits.

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