Integrating deep learning, threading alignments, and a multi‐MSA strategy for high‐quality protein monomer and complex structure prediction in CASP15

Wei Hui Zheng, Qiqige Wuyun, Lydia Freddolino, Yang Zhang

Proteins Structure Function and Bioinformatics 2023 article cited by 58

importance 7/10 partially solved Protein Structure and Dynamics structural biology stage: research

Predicting 3D structures of proteins and complexes, especially hard free-modeling targets, remains difficult.

Accurate protein structure prediction is a long-standing core problem in biology and medicine.

D-I-TASSER combined deep-learning restraints, threading alignments, multi-MSA ranking, and multi-domain modules for monomer prediction; DMFold-Multimer handled complexes, tested in the blind CASP15 experiment.

Average TM-score 19% higher than standard AlphaFold2 on 47 CASP15 free-modeling targets

Outperformed standard AlphaFold2 on the hardest blind-assessed CASP15 targets.

Venue Proteins Structure Function and Bioinformatics
Published 2023
Work type article
Authors Wei Hui Zheng, Qiqige Wuyun, Lydia Freddolino, Yang Zhang
Citations 58 (OpenAlex, at import time)
References 67
Model or method D-I-TASSER, DMFold-Multimer
Organization UM-TBM and Zheng groups (institutions not stated)
Primary source https://doi.org/10.1002/prot.26585
Open access hybrid
Keywords protein structure prediction, CASP15, D-I-TASSER, DMFold-Multimer, AlphaFold2
7 / 10

significant — thousands to millions affected

Protein structure prediction is a core problem in biology and medicine; gains shown on 47 CASP15 free-modeling targets and 38 complexes; foundational field, but abstract states no impact scale.

Basis: inferred. Judged from the source text, which gives no explicit scale. Stated scale: not stated in source. Method and limits.

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